International Journal of Oral Implantology & Clinical Research

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VOLUME 2 , ISSUE 1 ( January-April, 2011 ) > List of Articles

ORIGINAL ARTICLE

The Tumor Necrosis Factor-Alpha Gene-857 Single-Nucleotide Polymorphism Associated with Early Implant Failure in Asian Patients

Tetsuji Nakamoto, Ryuji Hosokawa, Yuhi Murashima, Chihiro Masaki, Michiko Makino, Tetsuro Kojo

Citation Information : Nakamoto T, Hosokawa R, Murashima Y, Masaki C, Makino M, Kojo T. The Tumor Necrosis Factor-Alpha Gene-857 Single-Nucleotide Polymorphism Associated with Early Implant Failure in Asian Patients. Int J Oral Implantol Clin Res 2011; 2 (1):1-6.

DOI: 10.5005/jp-journals-10012-1028

License: CC BY-ND 4.0

Published Online: 01-04-2011

Copyright Statement:  Copyright © 2011; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

This study examined the association between implant failure and IL-1β (+3954) and TNF-α (–857) gene polymorphisms in Japanese. Forty patients (mean age 64.1 years) were divided into a control group with one or more healthy implants (n = 27) and a test group with one or more implants that failed early (n = 13). Samples were collected from the buccal mucosa using spatula. Total genomic DNA was amplified using phi29 DNA polymerase. Genomic DNA from the buccal mucosa was amplified using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). The significance of the differences in the observed frequencies of the allele ratio and genotype distribution in both groups was assessed by Monte Carlo simulations using the program CLUMP. In the patient analysis, no significant differences were found in the allele or genotype distributions of the IL-1β gene between the control and test groups, and of TNF-α. In the implant analysis, no significant differences were noted in the allele or allele T-containing genotype distributions of IL-1β (+3954) between the control and test groups, whereas the allele distribution of TNF-α (–857) differed significantly between the two groups (p = 0.02). In the patient analysis, the patients possessing both genotypes, i.e. the allele T at IL-1β (+3954) and TNF-α (–857), the difference between the control and test groups was close to significance (p = 0.055). In the implant analysis, the patients possessing both genotypes, i.e. allele T at IL-1β (+3954) and TNF-α (–857) the difference between the control and test groups was significant (p = 0.008). This study suggests that possessing both the IL-1β (+3954) and TNF-α (–857) single-nucleotide polymorphisms (SNPs) constitutes a risk factor for early implant failure in Japanese.


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