International Journal of Oral Implantology & Clinical Research

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VOLUME 9 , ISSUE 1-3 ( January-December, 2018 ) > List of Articles

CASE REPORT

Autologous Osteoblast-cell Therapy in Orthodontics and Implantology: A Single-center Experience of Nine Patients

Dilip Deshpande

Keywords : Autologous osteoblast-cell therapy, Implant, Orthodontistry

Citation Information : Deshpande D. Autologous Osteoblast-cell Therapy in Orthodontics and Implantology: A Single-center Experience of Nine Patients. Int J Oral Implantol Clin Res 2018; 9 (1-3):55-59.

DOI: 10.5005/jp-journals-10012-1184

License: CC BY-NC 4.0

Published Online: 00-12-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Resorption of bone post tooth extraction is an established fact. In addition to this, pneumatization of maxillary sinuses further reduced the available bone and space for dental implant restoration. Traumatic loss of bone and bone loss due to cystic disease adds another dimension to clinical presentation and management. Various modalities have been used for bone replacement or restoration and are well documented. Here, we present a case series of nine patients, wherein a novel autologous cultured osteoblast cell product was used for bone augmentation in different clinical settings, with a quite satisfactory long-term outcome. We recommend the use of this revolutionary approach in rightly selected patients for permanent bone regeneration in the treatment of various oral and maxillofacial defects.


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  1. Albrektsson T, Zarb G, et al. The long term efficacy of currently used dental implants: a review and proposed criteria of success. Int J Oral Maxillofac Implants 1986;1:11–25.
  2. Chiapasco M, Casentini P, et al. Bone augmentation procedures in implant dentistry. Int J Oral Maxillofac Implants 2009;24(Suppl): 237–259.
  3. Misch CE. Maxillary sinus augmentation for endosteal implants: organized alternative treatment plans. Int J Oral Implantol 1987;4: 49–58.
  4. Tatum H. Maxillary and sinus implant reconstructions. Dent Clin North Am 1986;30:207–229.
  5. Jahangiri L, Devlin H, et al. Current perspective in residual ridge remodeling and its clinical implications: a review. J Prosthet Dent 1998;80:224–237. DOI: 10.1016/S0022-3913(98)70116-7.
  6. Cha H-S, Kim J-W, et al. Frequency of bone graft in implant surgery. Maxillofac Plast Reconstr Surg 2016;38:19. DOI: 10.1186/s40902-016-0064-2.
  7. Kumar P, Vanitha B, et al. Bone Grafts in Dentistry. J Pharm Bioallied Sci 2013;59(Suppl 1):S125–S127. DOI: 10.4103/0975-7406.113312.
  8. Giannoudis PV, Dinopoulos H, et al. Bone substitutes: an update. 2005;36(Suppl 3):S20–S27. DOI: 10.1016/j.injury.2005.07.029.
  9. Kim A, Kar K, et al. Subapical osteotomy to correct dental implant malpositioning and vertical ridge deficiency: a critical report. J Prosth Dent 2012;108:204–208. DOI: 10.1016/S0022-3913(12)00135-7.
  10. Sakkas A, Wilde F, et al. Autogenous bone grafts in oral implantology-is it still a “gold-standard”? a consecutive review of 279 patients with 456 clinical procedures. Int J Implant Dentistry 2017;3:23. DOI: 10.1186/s40729-017-0084-4.
  11. Sobhita G, Bobby J, et al. An overview of stem cell therapy in oral and maxillofacial surgery. Imp J Interdiscip Res 2017;3(10):504–509.
  12. Masaru K, Yosuke A, et al. Cell-based bone regeneration for alveolar ridge augmentation-Cell source, endogenous cell recruitment and immunomodulatory function. J Prosthodon Res 2015;59:96–112. DOI: 10.1016/j.jpor.2015.02.001.
  13. Meijer GJ, de Bruijn JD, et al. Cell based bone tissue engineering in jaw defects. Biomaterials 2008;29:3053–3061. DOI: 10.1016/j.biomaterials.2008.03.012.
  14. Shayesteh YS, Khojasteh A, et al. Sinus augmentation using human mesenchymal stem cells loaded into beta-tricalcium phosphate/hydroxyapatite scaffold. Oral Surg Oral Med Pathol Oral Radiol Endod 2008;106:203–209. DOI: 10.1016/j.tripleo.2007.12.001.
  15. McAllister BS, Haghighat K, et al. Histologic evaluation of a stem-cell based sinus-augmentation procedure. J Periodontol 2009;80: 679–686. DOI: 10.1902/jop.2009.080345.
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