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VOLUME 9 , ISSUE 1-3 ( January-December, 2018 ) > List of Articles


Hyperbaric Oxygen Therapy: Mechanism of Action and its Application in Periodontics: A Review

Harshita Gupta

Keywords : Implants, Periodontal diseases,Hyperbaric oxygen therapy

Citation Information : Gupta H. Hyperbaric Oxygen Therapy: Mechanism of Action and its Application in Periodontics: A Review. Int J Oral Implantol Clin Res 2018; 9 (1-3):11-16.

DOI: 10.5005/jp-journals-10012-1180

License: CC BY-NC 4.0

Published Online: 00-12-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Hyperbaric oxygen (HBO) therapy is widely used in a number of areas of medical practice. HBO increases local oxygen distribution, especially at the base of the periodontal pocket, which inhibits the growth of anaerobic bacteria and allows the ischemic tissues to receive an adequate intake of oxygen sufficient for a rapid recovery of cell metabolism, which may help to treat many periodontal diseases and also may act as a stimulator of osseointegration which would help during implant placement. The aim of this review article is to collect the information regarding the effects of HBO on periodontal diseases and dental implants. In conclusion, this review has shown that HBO may represent a useful aid, especially in combination with scaling and root planning (SRP), as far as nonsurgical periodontal therapy is concerned.

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  1. Mahale SA, Kalasva PK, et al. Hyperbaric oxygen therapy in periodontal diseases. J Int Clin Dent Res Organ 2013;5:3–8. DOI: 10.4103/2231-0754.134129.
  2. Popat RP, Popat PR. Role of hyperbaric oxygen therapy in the treatment of periodontitis. SRM J Res Dent Sci 2014;5:102–105. DOI: 10.4103/0976-433X.132082.
  3. Available
  4. Jain N, Deepa D. Applications of hyperbaric oxygen therapy in dentistry: A mini review. J Interdiscip Dent 2014;4:27–32. DOI: 10.4103/2229-5194.135007.
  5. Available
  6. Available
  7. Available
  8. Ertracht O, Arieli R, et al. Optimal oxygen pressure and time for reduced bubble formation in the N2-saturated decompressed prawn. J Appl Physiol 2005;98:1309–1313. DOI: 10.1152/japplphysiol.01051.2004.
  9. Available
  10. Available
  11. Available
  12. Boerema I, Meyne NG, et al. Life without blood. A study of the influence of high atmospheric pressure and hypothermia on dilution of the blood. J Cardiovascular Surg 1960;1:133–146.
  13. Available
  14. Nylander G, Lewis D, et al. Reduction of postischemic edema with hyperbaric oxygen. Plast Reconstr Surg 1985;76(4):596–603. DOI: 10.1097/00006534-198510000-00021.
  15. Waili NS. Hyperbaric Oxygen in the Treatment of Patients With Cerebral Stroke, Brain Trauma, and Neurologic Disease. Adv Ther 2005;22(6):659–678. DOI: 10.1007/BF02849960.
  16. Available
  17. Siddiqui A, Davidson JD, et al. Ischemic tissue oxygen capacitance after hyperbaric oxygen therapy: a new physiologic concept. Plast Reconstr Surg 1997;99:148–155. DOI: 10.1097/00006534-199701000- 00023.
  18. Hohn DC, Ponce B, et al. Antimicrobial systems of the surgical wound. I. A comparison of oxidative metabolism and microbicidal capacity of phagocytes from wounds and from peripheral blood. Am J Surg 1977;133:597–600. DOI: 10.1016/0002-9610(77)90018-6.
  19. Mirhij NJ, Roberts RJ, et al. Effects of hypoxemia upon aminoglycoside serum pharmacokinetics in animals. Antimicrob Agents Chemother 1978 Sep;14(3):344–347. DOI: 10.1128/AAC.14.3.344.
  20. Muhvich KH, Park MK, et al. Hyperoxia and the Antimicrobial Susceptibility of Escherichia coli and Pseudomonas aeruginosa. Antimicrob Agents Chemother 1989;33(9):1526–1530. DOI: 10.1128/AAC.33.9.1526.
  21. Yamanel L, Kaldirim U, et al. Ozone Therapy and Hyperbaric Oxygen Treatment in Lung Injury in Septic Rats. Int J Med Sci 2011;8(1):48–55. DOI: 10.7150/ijms.8.48.
  22. Smith JL. The pathological effects due to increase of oxygen tension in the air breathed. Ann Chim 1849;19–35.
  23. Prabowo S, Nataatmadja M, et al. Hyperbaric Oxygen Treatment in a Diabetic Rat Model Is Associated with a Decrease in Blood Glucose, Regression of Organ Damage and Improvement in Wound Healing. Health 2014;6:1950–1958. DOI: 10.4236/health.2014. 615228.
  24. Wadhawan R, Reddy Y, et al. Hyperbaric oxygen therapy; utility in medical & dental fields a review. J Sci 2014;4(10):604–614.
  25. Gottrup F. Oxygen in wound healing and infection. World J Surg 2004;28:312–315. DOI: 10.1007/s00268-003-7398-5.
  26. Tandara AA, Mustoe TA. Oxygen in wound healing-more than a nutrient. World J Surg 2004;28:294–300. DOI: 10.1007/s00268-003-7400-2.
  27. Sheikh AY, Gibson JJ, et al. Effect of hyperoxia on vascular endothelial growth factor levels in a wound model. Arch Surg 2000;135:1293–1297. DOI: 10.1001/archsurg.135.11.1293.
  28. Marx RE. Radiation injury to tissue. In: Kindwall EP. ed. Hyperbaric Medicine Practice, 2nd ed., Flagstaff (AZ): Best Publishing Company; 1999. pp. 665–723.
  29. Greenwood TW, Gilchrist AG. Hyperbaric oxygen and wound healing in post-irradiation head and neck surgery. Br J Surg 1973 May;60(5):394–397.
  30. Hadia HA, Smerdonb GR, et al. Hyperbaric oxygen therapy accelerates osteoblast differentiation and promotes bone formation. J Dent 2015;43:382–383. DOI: 10.1016/j.jdent.2014.10.006.
  31. Svalestad J, Thorsen E, et al. Effect of hyperbaric oxygen treatment on oxygen tension and vascular capacity in irradiated skin and mucosa. Int J Oral Maxillofac Surg 2013;1–6.
  32. Kessler L, Bilbault P, et al. Hyperbaric oxygenation accelerates the healing rate of nonischemic chronic diabetic foot ulcers. Diabetes Care 2003;26:2378–2382. DOI: 10.2337/diacare.26.8.2378.
  33. Thackham JA, McElwain DL, et al. The use of hyperbaric oxygen therapy to treat chronic wounds: A review. Wound Rep Reg 2008;16:321–330. DOI: 10.1111/j.1524-475X.2008.00372.x.
  34. Gupta V, Vijay S, et al. Hyperbaric Oxygen Therapy. JK-Practitioner 2005;12(1):44–47.
  35. Teughels W, Quirynen M, et al. Periodontal microbiology. In: Newman MG, Takei HH, et al. ed. Carranza's Clinical Periodontology, 11th ed., St. Louis, Missouri: Saunders Publication; 2012.
  36. Signoretto C, Bianchi F, et al. Microbiological evaluation of the effects of hyperbaric oxygen on periodontal disease. New Microbiol 2007;30:431–437.
  37. Tanaka M, Hanioka T, et al. Association of Oxygen Tension in Human Periodontal Pockets With Gingival Inflammation. J Periodontol 1998;69:1127–1130. DOI: 10.1902/jop.1998.69.10.1127.
  38. Mettraux GR, Gusberti FA, et al. Oxygen Tension (pO2) in Untreated Human Periodontal Pockets. J Periodontol 1984;55(9):516–521. DOI: 10.1902/jop.1984.55.9.516.
  39. Guentherman RH, Bishop JG, et al. The Effect of Increased Blood Oxygen Tensions on Induced Periodontal Disease. J Periodontol 1972;43(4):233–236. DOI: 10.1902/jop.1972.43.4.233.
  40. Manhold JH, Weisinger E, et al. Gingival tissue oxygenation: The effect of daily application of four commercial preparations. J Periodontol 1974;45:312–313. DOI: 10.1902/jop.1974.
  41. Available
  42. Schlagenhauf U, Horlacher V, et al. Repeated subgingival oxygen irrigations in untreated periodontal patients. J Clin Periodontol 1994;21:48–50.
  43. Issac AV, Mathew JJ, et al. Management of Chronic Periodontitis Using Subgingival Irrigation of Ozonized Water: A Clinical and Microbiological Study. J Clin Diagn Res 2015;9(8):ZC29–ZC33. DOI: 10.7860/JCDR/2015/14464.6303.
  44. Gaggl AJ, Rainer H, et al. Local oxygen therapy for treating acute necrotizing periodontal disease in smokers. J Periodontol 2006;77: 31–38. DOI: 10.1902/jop.2006.77.1.31.
  45. Available
  46. Chen TL, Xu B, et al. Effects of hyperbaric oxygen on aggressive periodontitis and subgingival anaerobes in Chinese patients. J Indian Soc Periodontol 2012;16:492–497. DOI: 10.4103/0972-124X. 106880.
  47. Wandawa G, Mustaqimah DN, et al. Efficacy of Hyperbaric Oxygen Therapy as an Adjunctive Therapy of Chronic Periodontitis. J Int Dent Med Res 2017;10(1):72–75.
  48. Available
  49. Available
  50. Johnsson K, Hansson A, et al. The Effects of Hyperbaric Oxygenation on Bone-Titanium Implant Interface Strength With and Without Preceding Irradiation. Int J Oral Maxillofac Implants 1993;8:415–419.
  51. Andersson G, Andreasson L, et al. Oral Implant Rehabilitation in Irradiated Patients Without Adjunctive Hyperbaric Oxygen. Int J Oral Maxillofac Implants 1998;13:647–654.
  52. Available
  53. Available
  54. Johnsson AA, Sawaii T, et al. A Histomorphometric Study of Bone Reactions to Titanium Implants in Irradiated Bone and the Effect of Hyperbaric Oxygen Treatment. Int J Oral Maxillofac Implants 1999;14:699–706.
  55. Granstrom G. Radiotherap, osseointegration and hyperbaric oxygen therapy. Periodontol 2000 2003;33:145–162.
  56. Teoh KH, Huryn JM, et al. Implant prosthodontic rehabilitation of the fibula-free flap reconstructed mandibles: a memorial sloan kettering cancer center review of prognostic factors and implant outcomes. Int J Oral Maxillofac Implants 2005;20:738–746.
  57. Brandt RL, Balanoff W. Immediate Placement of Implants and Appliance in an Irradiated Patient: A Case Study. Clin Implant Dent Relat Res 2007;9(2):116–119. DOI: 10.1111/j.1708-8208.2007.00037.x.
  58. Available
  59. Coulthard P, Patel S, et al. Hyperbaric oxygen therapy for irradiated patients who require dental implants: a Cochrane review of randomised clinical trials. Eur J Oral Implantol 2008;1(2): 105–110.
  60. Grecchi F, Zollino I, et al. A case of mandible osteonecrosis after a severe periimplant infection. Dent Res J 2012;9:S233–S236. DOI: 10.4103/1735-3327.109768.
  61. Nyberg J, Hertzman S, et al. Osseointegration of implants in irradiated with or without hyperbaric oxygen treatment: an experimental study in rat tibiae. Int J Oral Maxillofac Implants 2013;28:739–746. DOI: 10.11607/jomi.3083.
  62. Chambrone L, Mandia J, et al. Dental Implants Installed in Irradiated Jaws: A Systematic Review. J Dent Res 2013;92:119S–130S. DOI: 10.1177/0022034513504947.
  63. Shah DN, Chauhan CJ, et al. Effectiveness of hyperbaric oxygen therapy in irradiated maxillofacial dental implant patients: a systematic review with meta-analysis. J Indian Prosthodont Soc 2017;17:109–119. DOI: 10.4103/0972-4052.203193.
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