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VOLUME 7 , ISSUE 1 ( January-April, 2016 ) > List of Articles

CASE REPORT

Epithelioid Hemangioendothelioma of Mandible: A Rare Case Report with Immunohistochemical Studies

Deepak Verma, Mohamed Shareef, Shalini Varshney, Megha Verma

Citation Information : Verma D, Shareef M, Varshney S, Verma M. Epithelioid Hemangioendothelioma of Mandible: A Rare Case Report with Immunohistochemical Studies. Int J Oral Implantol Clin Res 2016; 7 (1):7-9.

DOI: 10.5005/jp-journals-10012-1145

License: CC BY-ND 4.0

Published Online: 01-04-2016

Copyright Statement:  Copyright © 2016; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

We report here a rare case of epithelioid hemangioendothelioma (EHE) of mandible in an adult male, who presented to our department with a huge mass protruding out of the oral cavity. The patient underwent wide local excision of the mass, and histopathological features favored the diagnosis of EHE, which was finally confirmed by immunohistochemistry with CD31 tumor marker.


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  1. Phillips H, Brown A, Ball M. Hemangioendothelioma: report of a case. J Oral Surg 1969 Apr;27(4):286-288.
  2. Weiss SW, Enzinger FM. Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma. Cancer 1982 Sep;50(5):970-981.
  3. Weiss SW, Ishak KG, Dail DH, Sweet DE, Enzinger FM. Epithelioid hemangioendothelioma and related lesions. Semin Diagn Pathol 1986 Nov;3(4):259-287.
  4. Rosai J, Gold J, Landy R. The histiocytoid hemangiomas: a unifying concept embracing several previously described entities of skin, soft tissue, large vessels, bone, and heart. Hum Pathol 1979 Nov;10(6):707-730.
  5. Angervall L, Kindblom LG, Karlsson K, Stener B. Atypical hemangioendothelioma of venous origin. A clinicopathologic, angiographic, immunohistochemical, and ultrastructural study of two endothelial tumors within the concept of histiocytoid hemangioma. Am J Surg Pathol 1985 Jul;9(7):504-516.
  6. Chi AC, Weathers DR, Folpe AL, Dunlap DT, Rasenberger K, Neville BW. Epithelioid hemangioendothelioma of the oral cavity: report of two cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005 Dec;100(6):717-724.
  7. Makhlouf HR, Ishak KG, Goodman ZD. Epithelioid hemangioendothelioma of the liver. Cancer 1999 Feb;85(3):562-582.
  8. Mentzel T, Beham A, Calonje E, Katenkamp D, Fletcher CD. Epithelioid hemangioendothelioma of skin and soft tissues: clinicopathologic and immunohistochemical study of 30 cases. Am J Surg Pathol 1997 Apr;21(4):363-374.
  9. Siddiqui MT, Evans HL, Ro JY, Ayala AG. Epithelioid hemangioendothelioma of the thyroid gland: a case report and review of literature. Histopathology 1998 May;32(5):473-476.
  10. Pigadas N, Mohamid W, McDermott P. Epithelioid hemangioendothelioma of the parotid gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000 Jun;89(6):730-738.
  11. Amin KS, McGuff HS, Cashman SW, Otto RA. Epithelioid hemangioendothelioma of the parotid gland with atypical features. Otolaryngol Head Neck Surg 2003 Nov;129(5):596-598.
  12. Triantafillidou K, Lazaridis N, Zaramboukas T. Epithelioid angiosarcoma of the maxillary sinus and the maxilla: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002 Sep;94(3): 333-337.
  13. Ellis GL, Kratochvil FJ 3rd. Epithelioid hemangioendothelioma of the head and neck: a clinicopathologic report of twelve cases. Oral Surg Oral Med Oral Pathol 1986 Jan;61(1): 61-68.
  14. Lang NP, Berglundh T, Heitz-Mayfield LJ, Pjetursson BE, Salvi GE, Sanz M. Consensus statements and recommended clinical procedures regarding implant survivals and complications. Int J Oral Maxillofac Implants 2004;19:150-154.
  15. Hanggi MP, Hanggi DC, Schoolfield JD, Meyer J, Cochran DL, Hermann JS. Crestal bone changes around titanium implants. Part I: a retrospective radiographic evaluation in humans comparing two non-submerged implant designs with different machined collar lengths. J Periodontol 2005 May;76(5):791-802.
  16. Monje A, Suarez F, Galindo-Moreno P, García-Nogales A, Fu JH, Wang HL. A systematic review on marginal bone loss around short dental implants (<10 mm) for implant-supported fixed prostheses. Clin Oral Implants Res 2014 Oct;25(10):1119-1124.
  17. Graziani F, Figuero E, Herrera D. Systematic review of quality of reporting, outcome measurements and methods to study efficacy of preventive and therapeutic approaches to peri-implant diseases. J Clin Periodontol 2012 Feb;39(Suppl 12):224-244.
  18. Augthun M, Tinschert J, Huber A. In vitro studies on the effect of cleaning methods on different implant surfaces. J Periodontol 1998 Aug;69(8):857-864.
  19. Unursaikhan O, Lee JS, Cha JK, Park JC, Jung UW, Kim CS, Cho KS, Choi SH. Comparative evaluation of roughness of titanium surfaces treated by different hygiene instruments. J Periodontal Implant Sci 2012 Jun;42(3):88-94.
  20. Karring ES, Stavropoulos A, Ellegaard B, Karring T. Treatment of peri-implantitis by the Vector system. Clin Oral Implants Res 2005 Jun;16(3):288-293.
  21. Renvert S, Samuelsson E, Lindahl C, Persson GR. Mechanical non-surgical treatment of peri-implantitis: a double-blind randomized longitudinal clinical study I: clinical results. J Clin Periodontol 2009 Jul,36(7):604-609.
  22. Mombelli A. Etiology, diagnosis, and treatment considerations in peri-implantitis. Curr Opin Periodontol 1997;4:127-136.
  23. Lang NP, Berglundh T, Heitz-Mayfield LJ, Pjetursson BE, Salvi GE, Sanz M. Consensus statements and recommended clinical procedures regarding implant survival and complications. Int J Oral Maxillofac Implants 2004,19(Suppl):150-154.
  24. Schmage P. Befundorientiertes Behandlungskonzept bei periimplantären Infektionen. Parodontol 2010;21:339-358.
  25. Schwarz F, Sahm N, Iglhaut G, Becker J. Impact of the method of surface debridement and decontamination on the clinical outcome following combined surgical therapy of peri-implantitis: a randomized controlled clinical study. J Clin Periodontol 2011 Mar;38(3):276-284.
  26. Schwarz F, Sahm N, Bieling K, Becker J. Surgical regenerative treatment of peri-implantitis lesions using a nanocrystalline hydroxyapatite or a natural bone mineral in combination with a collagen membrane: a four-year clinical follow-up report. J Clin Periodontol 2009 Sep;36(9):807-814.
  27. Schwarz F, Bieling K, Latz T, Nuesry E, Becker J. Healing of intrabony peri-implantitis defects following application of a nanocrystalline hydroxyapatite (Ostim) or a bovine-derived xenograft (Bio-Oss) in combination with a collagen membrane (Bio-Gide). A case series. J Clin Periodontol 2006 Jul;33(7):491-499.
  28. Park SH, Wang HL. Mucogingival pouch flap for sandwich bone augmentation: technique and rationale. Implant Dent 2005 Dec;14(4):349-354.
  29. Aghazadeh A, Rutger Persson G, Renvert S. A single-centre randomized controlled clinical trial on the adjunct treatment of intra-bony defects with autogenous bone or a xenograft: results after 12 months. J Clin Periodontol 2012 Jul;39(7):666-673.
  30. Lee A, Brown D, Wang HL. Sandwich bone augmentation for predictable horizontal bone augmentation. Implant Dent 2009 Aug;18(4):282-290.
  31. Lekovic V, Milinkovic I, Aleksic Z, Jankovic S, Stankovic P, Kenney EB, Camargo PM. Platelet-rich fibrin and bovine porous bone mineral vs platelet-rich fibrin in the treatment of intrabony periodontal defects. J Periodontal Res 2011 Aug;47(4):409-417.
  32. Bidra AS. No reliable evidence suggesting what is the most effective interventions for treating peri-implantitis. Evid Based Dent 2012 Jun;13(2):50-51.
  33. Kassenbaum DK, Dove SB, Cotton JA. Recognition and reporting of child abuse: Asurvey of dentist. Gen Dent. 1991;39:159-62.
  34. Da Fonseca MA. The important role of dental hygienists in the identification of child maltreatment. J Dent Hyg. 1993;67:135-9.
  35. Snibson GR. Collagen cross-linking: a new treatment paradigm in corneal disease — a review. Clin Exp Ophthalmol 2010 Mar;38(2):141-153.
  36. McCall AS, Kraft S, Edelhauser HF, Kidder GW, Lundquist RR, Bradshaw HE, Dedeic Z, Dionne MJ, Clement EM, Conrad GW. Mechanisms of corneal tissue cross-linking in response to treatment with topical riboflavin and long-wavelength ultraviolet radiation (UVA). Invest Ophthalmol Vis Sci 2010 Jan;51(1):129-138.
  37. Sorkina N, Varssano D. Corneal collagen, crosslinking: a systematic review. Ophthalmologica 2014 Apr;232(1):10-27.
  38. Steppat, MH.; Raiskup-Wolf, F.; Sporl, E.; Hoyer, A.; Pillunat, LE. Collagen cross linking in patients with pellucid marginal degeneration. Proceedings of the ARVO Meeting, April-May 2008, Florida, USA. 2008.
  39. Kymionis GD, Karavitaki AE, Kounis GA, Portaliou DM, Yoo SH, Pallikaris IG. Management of pellucid marginal corneal degeneration with simultaneous customized photorefractive keratectomy and collagen crosslinking. J Cataract Refract Surg 2009 Jul;35(7):1298-1301.
  40. Spadea L. Corneal collagen cross-linking with riboflavin and UVA irradiation in pellucid marginal degeneration. J Refract Surg 2010 May;26(5):375-377.
  41. Hassan Z, Nemeth G, Modis L, Szalai E, Berta A. Collagen cross-linking in the treatment of pellucid marginal degeneration. Indian J Ophthalmol 2014 Mar;62(3):367-370.
  42. Stojanovic A, Zhang J, Chen X, Nitter TA, Chen S, Wang Q. Topography-guided transepithelial surface ablation followed by corneal collagen cross-linking performed in a single combined procedure for the treatment of keratoconus and pellucid marginal degeneration. J Refract Surg 2010 Feb;26(2):145-152.
  43. Koller T, Schumacher S, Fankhauser F 2nd, Seiler T. Riboflavin/ultraviolet a crosslinking of the paracentral cornea. Cornea 2013 Feb;32(2):165-168.
  44. Han DCY, Lim L. Implantation of toric intraocular lens in pellucid marginal degeneration: a case report on ocular aberrometry outcome. J Clin Exp Ophthalmol 2012 Jan;3:204.
  45. Bahar I, Bialer O. Cataract extraction and Toric intraocular lens implantation for the management of Pellucid marginal degeneration and cataract. Int J Keratoco Ectatic Corneal Dis 2012 Jan-Apr;1(1):66-67.
  46. de Vries NE, Tahzib NG, Webers CA, Hendrikse F, Nuijts RM. Use of verisyse/artisan phakic intraocular lens for the reduction of myopia in a patient with pellucid marginal degeneration. Cornea 2008 Feb;27(2):241-245.
  47. Camoriano GD, Aman-Ullah M, Purba MK, Sun J, Gimbel HV. Toric collagen copolymer phakic intraocular lens to correct myopic astigmatism in eyes with pellucid marginal degeneration. J Cataract Refract Surg 2012 Feb;38(2):256-261.
  48. Varley GA, Macsai MS, Krachmer JH. The results of penetrating keratoplasty for pellucid marginal corneal degeneration. Am J Ophthalmol 1990 Aug;110(2):149-152.
  49. Speaker MG, Arentsen JJ, Laibson PR. Long-term survival of large diameter penetrating keratoplasties for keratoconus and pellucid marginal degeneration. Acta Ophthalmol Suppl 1989;192:17-19.
  50. Jinabhai A, Radhakrishnan H, O'Donnell C. Pellucid corneal marginal degeneration: a review. Contact Lens Anterior Eye 2011 Apr;34(2):56-63.
  51. Kaushal S, Jhanji V, Sharma N, Tandon R, Titiyal JS, Vajpayee RB. “Tuck In” lamellar keratoplasty (TILK) for corneal ectasias involving corneal periphery. Br J Ophthalmol 2008 Feb;92(2):286-290.
  52. Schanzlin DJ, Sarno EM, Robin JB. Crescentic lamellar keratoplasty for pellucid marginal degeneration. Am J Ophthalmol 1983 Aug;96(2):253-254.
  53. Kremer I, Sperber LT, Laibson PR. Pellucid marginal degeneration treated by lamellar and penetrating keratoplasty. Arch Ophthalmol 1993 Feb;111(2):169-170.
  54. Rasheed K, Rabinowitz YS. Surgical treatment of advanced pellucid marginal degeneration. Ophthalmology 2000 Oct;107(10):1836-1840.
  55. Jabbarvand M, Hashemian H, Khodaparast M, Hassanpour N, Mohebbi M. Intrastromal lamellar keratoplasty in patients with pellucid marginal degeneration. J Cataract Refract Surg 2015 Jan;41(1):2-8.
  56. MacLean H, Robinson LP, Wechsler AW. Long-term results of corneal wedge excision for pellucid marginal degeneration. Eye (Lond) 1997;11(Pt 5):613-617.
  57. Javadi MA, Karimian F, Hosseinzadeh A, Noroozizadeh HM, Sa'eedifar MR, Rabie HM. Lamellar crescentic resection for pellucid marginal corneal degeneration. J Refract Surg 2004 Mar-Apr;20(2):162-165.
  58. Fronterre A, Portesani GP. Epikeratoplasty for pellucid marginal corneal degeneration. Cornea 1991 Sep;10(5):450-453.
  59. Ramez Barbara J, Barbara R, Zadok D, et al. Collagen Corneal Cross-Linking followed by Intac Implantation in a Case of Post-PRK Ectasia. Int J Keratoco Ectatic Corneal Dis 2012;1(1):68-72.
  60. Yeung SN, Ku JYF, Lichtinger A, Low SAW, Kim P, Rootman DS. Efficacy of single or paired intrastromal corneal ring segment implantation combined with collagen crosslinking in keratoconus. J Cataract Refract Surg 2013 Aug;39(8):1146-1151.
  61. Kiliç A, Kamburoglu G, Akinci A. Riboflavin injection into the corneal channel for combined collagen crosslinking and intrastromal corneal ring segment implantation. J Cataract Refract Surg 2012 May;38(5):878-883.
  62. Ferenczy PA, Dalcegio M, Koehler M, Pereira TS, Moreira H, Bugmann ML. Femtosecond-assisted intrastromal corneal ring implantation for keratoconus treatment: a comparison with crosslinking combination. Arq Bras Oftalmol 2015 Mar-Apr;78(2):76-81.
  63. Baikoff G, Joly P. Comparison of minus power anterior chamber intraocular lenses and myopic epikeratoplasty in phakic eyes. Refract Corneal Surg 1990 Jul-Aug;6(4):252-260.
  64. Baikoff G. Phakic anterior chamber intraocular lenses. Int Ophthalmol Clin 1991 Winter;31(1):75-86.
  65. Fechner PU, Worst JG. A new concave intraocular lens for the correction of myopia. Eur J Implant Refract Surg 1989 Mar;1(1):41-43.
  66. Brauweiler PH, Wehler T, Busin M. High incidence of cataract formation after implantation of a silicone posterior chamber lens in phakic, highly myopic eyes. Ophthalmology 1999 Sep;106(9):1651-1655.
  67. Zhang X, Tao X-C, Li Z-W, Zhou W-Y, Ma P, Zhang C-X, Wang Y-M, Mu G-Y. Combining corneal crosslinking and phakic toric implantable collamer lenses for the treatment of keratectasia: a case report. Exp Ther Med 2016 Sep;12(3):1495-1498.
  68. Cakir H, Utine CA. Combined kerarings and Artisan/Artiflex IOLs in keratectasia. J Refract Surg 2011 Feb;27(2):119-126.
  69. Moshirfar M, Fenzl CR, Meyer JJ, Neuffer MC, Espandar L, Mifflin MD. Simultaneous and sequential implantation of Intacs and verisyse phakic intraocular lens for refractive improvement in keratectasia. Cornea 2011 Feb;30(2):158-163.
  70. Thompson RW Jr, Price MO, Bowers PJ, Price FW Jr. Long-term graft survival after penetrating keratoplasty. Ophthalmology 2003 Jul;110(7):1396-1402.
  71. McAllum PJ, Segev F, Herzig S, Rootman DS. Deep anterior lamellar keratoplasty for post-LASIK ectasia. Cornea 2007 May;26(4):507-511.
  72. Villarrubia A, Perez-Santonja JJ, Palacin E, Rodriguez-Ausin PP, Hidalgo A. Deep anterior lamellar keratoplasty in post-laser in situ keratomileusis keratectasia. J Cataract Refract Surg 2007 May;33(5):773-778.
  73. Grewal S, Laibson PR, Cohen EJ, Rapuano CJ. Acute hydrops in the corneal ectasias: Associated factors and outcomes. Trans Am Ophthalmol Soc 1999;97:187-98.
  74. Koenig SB, Smith RW. Keratoconus and corneal hydrops associated with compulsive eye rubbing. Refract Corneal Surg 1993;9:383-84.
  75. Mashor RS, Kumar NL, Ritenour RJ, Rootman DS. Keratoconus caused by eye rubbing in patients with Tourette syndrome. Can J Ophthalmol 2011;46:83-86.
  76. Kandarakis A, Karampelas M, Soumplis V, et al. A case of bilateral self-induced keratoconus in a patient with Tourette syndrome associated with compulsive eye rubbing: Case report. BMC Ophthalmol 2011;11:28.
  77. Coyle JT. Keratoconus and eye rubbing. Am J Ophthalmol 1984;97:527-28.
  78. Gritz DC, McDonnell PJ. Keratoconus and ocular massage. Am J Ophthalmol 1988;106:757-58.
  79. Rahi A, Davies P, Ruben M, et al. Keratoconus and coexisting atopic disease. Br J Ophthalmol 1977;61:761-64.
  80. Besancon G, Baikoff G, Deneux A, et al. Preliminary note on the psychological and mental status of patients with keratoconus. Bull Soc Ophtalmol Fr 1980;80:441-43.
  81. Copeman PW. Eczema and keratoconus. Br Med J 1965;2: 977-79.
  82. Mannis MJ, Morrison TL, Zadnik K, et al. Personality trends in keratoconus. An analysis. Arch Ophthalmol 1987;105:798-800.
  83. Swartz NG, Cohen EJ, Scott DG, et al. Personality and keratoconus. CLAO J 1990;16:62-64.
  84. Gasset AR, Hinson WA, Frias JL. Keratoconus and atopic diseases. Ann Ophthalmol 1978;10:991-94.
  85. Kaya V, Karakaya M, Utine CA, et al. Evaluation of the corneal topographic characteristics of keratoconus with orbscan II in patients with and without atopy. Cornea 2007;26:945-48.
  86. Galin MA, Berger R. Atopy and keratoconus. Am J Ophthalmol 1958;45:904-06.
  87. Roth HL, Keirland RR. The natural history of atopic dermatitis. A 20-year follow-up study. Arch Dermatol 1964;89:209-14.
  88. Lowell FC, Carroll JM. A study of the occurrence of atopic traits in patients with keratoconus. J Allergy 1970;46:32-39.
  89. Nemet AY, Vinker S, Bahar I, Kaiserman I. The association of keratoconus with immune disorders. Cornea 2010;29:1261-64.
  90. Buddi R, Lin B, Atilano SR, et al. Evidence of oxidative stress in human corneal diseases. J Histochem Cytochem 2002;50: 341-51.
  91. Kenney MC, Brown DJ. The cascade hypothesis of keratoconus. Cont Lens Anterior Eye 2003;26(3):139-46.
  92. Behndig A, Karlsson K, Johansson BO, et al. Superoxide dismutase isoenzymes in the normal and diseased human cornea. Invest Ophthalmol Vis Sci 2001;42:2293-96.
  93. Podskochy A, Fagerholm P. The expression of Fas ligand protein in ultraviolet-exposed rabbit corneas. Cornea 2002;21:91-94.
  94. Newkirk KM, Chandler HL, Parent AE, et al. Ultraviolet radiation-induced corneal degeneration in 129 mice. Toxicol Pathol 2007;35:819-26.
  95. Pettenati MJ, Sweatt AJ, Lantz P, et al. The human cornea has a high incidence of acquired chromosome abnormalities. Hum Genet 1997;101:26-29.
  96. Snibson GR. Collagen cross-linking: A new treatment paradigm in corneal disease—a review. Clin Experiment Ophthalmol 2010;38:141-53.
  97. Spoerl E, Raiskup-Wolf F, Kuhlisch E, Pillunat LE. Cigarette smoking is negatively associated with keratoconus. J Refract Surg 2008;24:S737-40.
  98. Rabinowitz YS, Nesburn AB, McDonnell PJ. Videokeratography of the fellow eye in unilateral keratoconus. Ophthalmology 1993;100:181-86.
  99. Goodrich DW, Lee WH. The molecular genetics of retinoblastoma. Cancer Surv 1990;9:529-54.
  100. Moodaley LC, Woodward EG, Liu CS, Buckley RJ. Life expectancy in keratoconus. Br J Ophthalmol 1992;76:590-91.
  101. Honein MA, Dawson AL, Petersen EE, Jones AM, Lee EH, Yazdy MM, Ahmad N, Macdonald J, Evert N, Bingham A, et al. Birth defects among fetuses and infants of US women with evidence of possible Zika virus infection during pregnancy. JAMA 2017 Jan 3;317(1):59-68.
  102. Chervenak FA, Jeanty P, Cantraine F, Chitkara U, Venus I, Berkowitz RL, Hobbins JC. The diagnosis of fetal microcephaly. Am J Obstet Gynecol 1984 Jul 1;149(5):512-517.
  103. Papageorghiou AT, Thilaganathan B, Bilardo CM, Ngu A, Malinger G, Herrera M, Salomon LJ, Riley LE, Copel JA. ISUOG Interim Guidance on ultrasound for Zika virus infection in pregnancy: information for healthcare professionals. Ultrasound Obstet Gynecol 2016 Apr;47(4):530-532.
  104. Chibueze EC, Parsons AJ, Lopes KD, Yo T, Swa T, Nagata C, Horita N, Morisaki N, Balogun OO, Dagvadorj A, et al. Diagnostic accuracy of ultrasound scanning for prenatal microcephaly in the context of Zika virus infection: a systematic review and meta-analysis. Sci Rep 2017 May 23;7(1):2310.
  105. Cordeiro MT. Zika virus: laboratory diagnosis. In: Zika in focus. Springer International Publishing; 2017. pp. 59-62.
  106. Mlakar J, Korva M, Tul N, Popović M, Poljšak-Prijatelj M, Mraz J, Kolenc M, Resman Rus K, Vesnaver Vipotnik T, Fabjan Vodušek V, et al. Zika virus associated with microcephaly. N Engl J Med 2016 Mar 10;374(10):951-958.
  107. Zare Mehrjardi M, Keshavarz E, Poretti A, Hazin AN. Neuroimaging findings of Zika virus infection: a review article. Jpn J Radiol 2016 Dec;34(12):765-770.
  108. Oliveira Melo AS, Malinger G, Ximenes R, Szejnfeld PO, Alves Sampaio S, Bispo de Filippis AM. Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg? Ultrasound Obstet Gynecol 2016 Jan;47(1):6-7.
  109. Araujo AQ, Silva MT, Araujo AP. Zika virus-associated neurological disorders: a review. Brain 2016;139(8):2122-2130.
  110. Brasil P, Pereira JP Jr, Moreira ME, Ribeiro Nogueira RM, Damasceno L, Wakimoto M, Rabello RS, Valderramos SG, Halai UA, Salles TS, et al. Zika virus infection in pregnant women in Rio de Janeiro. N Engl J Med 2016 Dec 15;375(24):2321-2334.
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